Inhibiting γ-secretase worsens the memory deficit of FDD
mice. Mice were injected in the lateral ventricle with either 1μl of PBS or 1μl of PBS/3μM compound-E. Mice where injected once, 1 hour prior to the training. a. FDDKI mice, regardless of whether they were injected with vehicle alone of GSI, spent the same amount of time exploring the two identical objects in the training trial. b. FDDKI mice injected with PBS spent more time exploring the novel object 4 hours later, showing normal object recognition, while FDDKI mice treated with GSI present a statistically significant novel object recognition deficit. c. There is no statistically significant difference in exploratory activity between treated and untreated FDDKI mice.