TY - JOUR AU - Tong, Youren AU - Giaime, Emilie AU - Yamaguchi, Hiroo AU - Ichimura, Takaharu AU - Liu, Yumin AU - Si, Huiqing AU - Cai, Huaibin AU - Bonventre, Joseph V. AU - Shen, Jie PY - 2012 DA - 2012/01/09 TI - Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway JO - Molecular Neurodegeneration SP - 2 VL - 7 IS - 1 AB - Dominantly inherited missense mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, but its normal physiological function remains unclear. We previously reported that loss of LRRK2 causes impairment of protein degradation pathways as well as increases of apoptotic cell death and inflammatory responses in the kidney of aged mice. SN - 1750-1326 UR - https://doi.org/10.1186/1750-1326-7-2 DO - 10.1186/1750-1326-7-2 ID - Tong2012 ER -