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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Quantitative connection between polyglutamine aggregation kinetics and neurodegenerative process in patients with Huntington’s disease

Figure 5

Progression of illness in SCA3 patients may be expressed by a sigmoidal function. (A) The relative risk of neuronal damage for each polyQ-length was derived from the regression model shown in Figure 4A. The risk of neuronal damage with a repeat number of 60 was defined as 1, and the relative risk of neuronal damage with a repeat number of 65 was calculated as age of onset for 60 repeats/age of onset for 65 repeats. (B-D) Data on the correlation between polyQ-length and quantified changes in brain atrophy as visualized by MR imaging [41] were re-evaluated using the relative risk of neuronal damage based on polyQ size. (B) The age of onset in patients analyzed by MR imaging was transformed as 1/age of onset, and correlated with the relative risk of neuronal damage based on polyQ size. Linear correlations between the relative risks of neuronal damage based on polyQ size and the age-adjusted degree of atrophy in the pontine tegmentum (C) and midbrain (D).

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