Figure 6
Correlation between polyQ-length and age of onset in patents with HD. A total of 312 patients with expanded CAG repeats in the HD gene were analyzed. (A) Linear regression analysis of natural log-transformed tA versus polyQ size. (B) Residual analysis of standardized residuals versus standardized predicted values in the regression model of Figure 6A showed a U-shaped trend in the residual distribution. (C) Linear regression analysis using Eq. 20 with natural log-transformed (tA2 – addt2)1/2 data against polyQ size provided the best fit to a linear model when addt2 = 217. The addt2 value was determined by identifying the points at which the R2 were identical for a quadratic curve (red line) and a linear model (black line). (D) Residual analysis of standardized residuals versus standardized predicted values in the regression model of Figure 6C showed that the residual distribution was normal. (E) Linear regression analysis using Eq. 11 (see Methods) with natural log-transformed (tA – h) versus polyQ-length to provide the best fit to a linear model when h = 13.9. (F) Residual analysis of standardized residuals versus standardized predicted values in the regression model of Figure 6D showed that the residual distribution was normal.