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Figure 4 | Molecular Neurodegeneration

Figure 4

From: Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia

Figure 4

SB-3CT inhibits elevated MMP-9 activity after embolus-induced MCA occlusion in mice. a Gelatin zymography reveals increased levels of MMP-9 zymogen (proMMP-9) and activated (act.MMP-9) enzyme in embolus-induced focal cerebral ischemia, and SB-3CT treatment attenuated the increase in proMMP-9 and act.MMP-9. Under these experimental conditions, proMMP-2 was not altered. b Quantification of relative MMP-9 gelatinolytic activity (n = 3) *, p < 0.05 by one-tailed Student’s t-test; data are expressed as means ± SEM.

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Molecular Neurodegeneration

ISSN: 1750-1326