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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Regulation of mitochondrial permeability transition pore by PINK1

Figure 5

Blockade of mPTP opening attenuates the defect in mitochondrial transmembrane potential in PINK1 −/− MEFs. A. Representative flow cytometry dot plots showing TMRM fluorescence in PINK1−/− and +/+ cells incubated with TMRM (50 nM) and atractylate (20 μM), CsA (1 μM), BkA (10 μM), FK-506 (5 μM) or Co2+ (1 mM). B. The bar graph shows mitochondrial membrane potential measured by TMRM fluorescence after FACS analysis following various treatment, atractylate (20 μM), CsA (1 μM), BkA (10 μM), FK-506 (5 μM) or Co2+ (1 mM). The number shown in the panel indicates the number of independent experiments performed. All data are expressed as mean ± SEM. * p < 0.05.

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