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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome

Figure 3

Postsynaptic mechanisms underlying the LTP facilitation by Grp1 mGluRs inhibition. Paired-pulse facilitation (the ratio of EPSC2/EPSC1) was recorded with intervals of 35, 50, 75, 100, and 150 ms. (A) Representative traces of PPF with an interval of 50 ms recorded in the Fmr1 WT mice ACC. (B) PPF was not changed at each interval in Fmr1 WT mice after perfusion of DL-AP3 (10 μM) or/and SKF81297 (5 μM) (n = 6 slices/3 mice in each group). (C) Representative traces of PPF with an interval of 50 ms recorded in the Fmr1 KO mice ACC. (D) PPF was not changed at each interval in Fmr1 KO mice after perfusion of DL-AP3 (10 μM) or/and SKF81297 (5 μM) (n = 6 slices/3 mice in each group).

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Molecular Neurodegeneration

ISSN: 1750-1326