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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome

Figure 5

Expression of GluR1 in cultured cortical neurons. (A) Representatives of western blot to detect the total expression of AMPA receptor GluR1 subunit. (B) Total expression of GluR1 was increased after treatment with SKF81297 (5 μM) alone or combining with DL-AP3 (10 μM) in the neurons form Fmr1 WT mice (n = 4 dishes). (C) Representatives of western blot to detect the surface expression of AMPA receptor GluR1 subunit. (D) Surface expression of GluR1 was increased after treatment with SKF81297 (5 μM) alone or combining with DL-AP3 (10 μM) in neurons from Fmr1 WT and KO mice. (E) Forskolin (10 μM) alone or combining with DL-AP3 (10 μM) increased the total expression levels of GluR1 in the cultures from Fmr1 WT mice but not from KO mice. (F) Surface expression of GluR1 was increased after treatment with forskolin (10 μM) alone or combining with DL-AP3 (10 μM) in neurons from Fmr1 WT and KO mice. n = 4 dishes. * p < 0.05, ** p < 0.01 compared with control; # p < 0.05, ## p < 0.01 compared between Fmr1 WT and KO mice; &p < 0.05 compared between the neurons treated with SKF81297 and DL-AP3 + SKF81297 in Fmr1 KO mice.

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