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Table 1 Assay for disease mechanism using transgenic animals

From: Does a loss of TDP-43 function cause neurodegeneration?

Transgene expression

Disease mechanism

TDP-43

 

GF

LF

DN

Fly(a)

Fish(b)

Rod.(c)

OE mutant

+

-

+

+

+

+

OE WT

−/+

-

−/+

+

+

+

KO or KD

-

+

+

+

+

?

  1. OE = overexpression; KO = knockout; KD = knockdown;
  2. GF = Gain of function; DN = Dominant negative; LF = Loss of function
  3. Rod. = rodents; + = positive for neurological phenotype
  4. - = negative for neurological phenotype; ? = remains to be determined
  5. See the text for detailed explanation and references for the models.
  6. (a) reference [30–34]; (b) reference [35]
  7. (c) reference [12, 23–27, 36–43]
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Molecular Neurodegeneration

ISSN: 1750-1326