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Table 1 Assay for disease mechanism using transgenic animals

From: Does a loss of TDP-43 function cause neurodegeneration?

Transgene expression Disease mechanism TDP-43
  GF LF DN Fly(a) Fish(b) Rod.(c)
OE mutant + - + + + +
OE WT −/+ - −/+ + + +
KO or KD - + + + + ?
  1. OE = overexpression; KO = knockout; KD = knockdown;
  2. GF = Gain of function; DN = Dominant negative; LF = Loss of function
  3. Rod. = rodents; + = positive for neurological phenotype
  4. - = negative for neurological phenotype; ? = remains to be determined
  5. See the text for detailed explanation and references for the models.
  6. (a) reference [3034]; (b) reference [35]
  7. (c) reference [12, 2327, 3643]