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Table 1 Description of cohorts.

From: Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

  Stage I: Flanders-Belgian AD cohort Stage II: Lille AD cohort Stage II: Toronto AD cohort Stage III: Caribbean Hispanic AD cohort
Total number of subjects 1930 2182 573 1045
AD patients 1057 1465 323 520
Mean AAO (years) (SD) 74.9 ± 8.9 69.5 ± 8.2 75.3 ± 9.7 79.7 ± 8.6
Women (%) 692 (65.5) 969 (66.1) 178 (55.1) 369 (71.0)
At least one APOE ε4 allele (%) 565 (53.5) 852 (58.2) 182 (56.3) 207 (39.9)
Control individuals 873 717 250 525
Mean AAI (years) (SD) 65.1 ± 14.9 74.0 ± 8.0 73.0 ± 10.2 78.9 ± 6.5
Women (%) 501 (57.4) 447 (62.3) 149 (60.0) 358 (68.2)
At least one APOE ε4 allele (%) 235 (26.9) 145 (20.2) 60 (24.0) 126 (24.0)
  1. AAO = age at onset; SD = standard deviation; AAI = age at inclusion.