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Table 4 Meta-analysis of rare CLU genetic variants.

From: Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

  Total chromosome number Rare genetic variants  
  AD C AD (%) C (%) OR [95% CI]
Flanders-Belgian (this study) 1698 1318 21 (1.2) 9 (0.7) 1.82 [0.8-3.39]
Lille (this study) 2610 1220 21 (0.8) 3 (0.2) 3.29 [0.98-11.05]
Toronto (this study) 612 462 6 (1.0) 2 (0.4) 2.28 [0.46-11.33]
Portugal (Guerreiro et al.) 14 806 470 9 (1.1) 2 (0.4) 2.64 [0.57-12.28]
UK (Guerreiro et al.) 14 892 1264 2 (0.2) 2 (0.2) 1.42 [0.20-10.09]
US-Caucasian (Tycko et al.) 15 106 86 1 (0.9) 3 (3.5) 0.26 [0.03-2.58]
Summary 6724 4820 60 (0.9) 21 (0.4) 1.96 [1.18-3.25]
      pMH = 0.009
      pwoolf = 0.551
  1. Total allele counts and frequencies of rare non-synonymous substitutions affecting the CLU β-chain observed in AD patients and control individuals. P-values are given for fixed-effect Mantel-Haenszel test (pMH) and Woolf's test for heterogeneity (pwoolf). Odds ratios are given with 95% confidence intervals; summary odds ratio is based on a fixed-effect Mantel-Haenszel meta-analysis. Significant associations are depicted in bold. Compared to our p.R338W finding, Guerreiro and colleagues14 observed another non-synonymous substitution at codon 338 in 1 AD patient 5 (p.R338Q).