(A) Allelic associations in stage I and II AD cohorts
| | | | | | | | | |
---|
| |
Belgian-Flanders
| | |
Lille
| | | |
Toronto
| | | |
---|
|
Allele
|
AD (total)
|
C (total)
|
OR [95% CI]
|
p
|
AD (total)
|
C (total)
|
OR [95% CI]
|
p
|
AD (total)
|
C (total)
|
OR [95% CI]
|
p
|
---|
rs867230
|
T
|
0.63 (1259)
|
0.59 (952)
| |
0.074 (1)
|
0.66 (1736)
|
0.62 (742)
| |
0.022
(1)
|
0.60 (367)
|
0.63 (307)
| |
0.288 (1)
|
Intron 1
|
G
|
0.37 (752)
|
0.41 (670)
|
0.82 [0.70-0.96]
|
0.012
(2)
|
0.34 (904)
|
0.38 (456)
|
0.89 [0.76-1.04]
|
0.144 (2)
|
0.40 (247)
|
0.37 (181)
|
1.04 [0.80-1.36]
|
0.771 (2)
|
rs1532278
|
G
|
0.63 (1308)
|
0.61 (1006)
| |
< 0.01
(1)
|
0.675 (1789)
|
0.628 (764)
| |
0.004
(1)
|
0.62 (383)
|
0.62 (301)
| |
0.996 (1)
|
Intron 3
|
A
|
0.37 (770)
|
0.40 (656)
|
0.83 [0.71-0.97]
|
0.019
(2)
|
0.325 (861)
|
0.372 (452)
|
0.83 [0.71-0.97]
|
0.02
(2)
|
0.38 (233)
|
0.38 (183)
|
1.27 [0.97-1.64]
|
0.078 (2)
|
rs11136000
|
G
|
0.65 (1232)
|
0.61 (990)
| |
0.034
(1)
|
0.66 (1707)
|
0.628 (764)
| |
0.195 (1)
|
0.61 (372)
|
0.63 (299)
| |
0.645 (1)
|
Intron 3
|
A
|
0.35 (676)
|
0.39 (630)
|
0.79 [0.68-0.93]
|
0.004
(2)
|
0.34 (875)
|
0.372 (452)
|
0.93 [0.79-1.10]
|
0.400 (2)
|
0.39 (236)
|
0.37 (179)
|
1.00 [0.77-1.31]
|
0.986 (2)
|
rs9331908
|
G
|
0.66 (1389)
|
0.69 (1161)
| |
0.055 (1)
|
0.62 (1712)
|
0.66 (841)
| |
0.036
(1)
|
0.66 (416)
|
0.69 (338)
| |
0.297 (1)
|
Intron 4
|
A
|
0.34 (713)
|
0.31 (521)
|
1.18 [1.01-1.39]
|
0.035
(2)
|
0.38 (1046)
|
0.35 (443)
|
1.12 [0.96-1.30]
|
0.156 (2)
|
0.34 (214)
|
0.31 (152)
|
1.20 [0.91-1.56]
|
0.198 (2)
|
rs7982
|
C
|
0.63 (1228)
|
0.61 (1005)
| |
0.191 (1)
|
0.67 (1780)
|
0.63 (804)
| |
0.022
(1)
|
0.62 (374)
|
0.60 (295)
| |
0.434 (1)
|
Exon 5
|
T
|
0.37 (734)
|
0.40 (657)
|
0.85 [0.73-0.99]
|
0.037
(2)
|
0.33 (884)
|
0.37 (470)
|
0.89 [0.76-1.03]
|
0.124 (2)
|
0.38 (234)
|
0.36 (167)
|
1.16 [0.89-1.52]
|
0.273 (2)
|
(B) Meta-analysis of stage I and II AD cohorts
| | | | | | | | | |
|
Allele
|
Summary OR
|
p
MH
|
p
Bonf
|
p
woolf'
| | | | | | | | |
rs867230
|
T
| | | | | | | | | | | | |
Intron 1
|
G
|
0.88 [0.79-0.97]
|
0.013
|
0.065
|
0.311
| | | | | | | | |
rs1532278
|
G
| | | | | | | | | | | | |
Intron 3
|
A
|
0.85 [0.77-0.94]
|
0.001
|
0.005
|
0.648
| | | | | | | | |
rs11136000
|
G
| | | | | | | | | | | | |
Intron 3
|
A
|
0.88 [0.79-0.97]
|
0.013
|
0.065
|
0.206
| | | | | | | | |
rs9331908
|
G
| | | | | | | | | | | | |
Intron 4
|
A
|
1.16 [1.04-1.28]
|
0.006
|
0.030
|
0.824
| | | | | | | | |
rs7982
|
C
| | | | | | | | | | | | |
Exon 5
|
T
|
0.89 [0.80-0.98]
|
0.023
|
0.115
|
0.448
| | | | | | | | |
- (A) Allele frequencies are shown with absolute numbers in brackets. (1) The first p-value is the 2-sided p-value of the unadjusted χ2 statistics, (2) The second p-value is adjusted for age, APOE status and gender. Calculations of odds ratios (OR), presented with 95% confidence intervals (CI), were performed using the common allele as reference allele. (B) For meta-analysis, Mantel-Haenszel summary OR ratios are given with 95% CI and corresponding p-values (pMH) based on fixed-effects meta-analysis of age, gender and APOE- adjusted effect estimates of the minor allele. Nominal p-values (pmh, adjusted for age, gender and APOE effects) and Bonferroni corrected p-values (p Bonf) for the number of SNPs (N = 5) in the meta-analysis are given. P-values of Woolf's test for heterogeneity (p-woolf) are given.