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Table 6 Common CLU associations with AD.

From: Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

(A) Allelic associations in stage I and II AD cohorts          
   Belgian-Flanders    Lille     Toronto    
  Allele AD (total) C (total) OR [95% CI] p AD (total) C (total) OR [95% CI] p AD (total) C (total) OR [95% CI] p
rs867230 T 0.63 (1259) 0.59 (952)   0.074 (1) 0.66 (1736) 0.62 (742)   0.022 (1) 0.60 (367) 0.63 (307)   0.288 (1)
Intron 1 G 0.37 (752) 0.41 (670) 0.82 [0.70-0.96] 0.012 (2) 0.34 (904) 0.38 (456) 0.89 [0.76-1.04] 0.144 (2) 0.40 (247) 0.37 (181) 1.04 [0.80-1.36] 0.771 (2)
rs1532278 G 0.63 (1308) 0.61 (1006)   < 0.01 (1) 0.675 (1789) 0.628 (764)   0.004 (1) 0.62 (383) 0.62 (301)   0.996 (1)
Intron 3 A 0.37 (770) 0.40 (656) 0.83 [0.71-0.97] 0.019 (2) 0.325 (861) 0.372 (452) 0.83 [0.71-0.97] 0.02 (2) 0.38 (233) 0.38 (183) 1.27 [0.97-1.64] 0.078 (2)
rs11136000 G 0.65 (1232) 0.61 (990)   0.034 (1) 0.66 (1707) 0.628 (764)   0.195 (1) 0.61 (372) 0.63 (299)   0.645 (1)
Intron 3 A 0.35 (676) 0.39 (630) 0.79 [0.68-0.93] 0.004 (2) 0.34 (875) 0.372 (452) 0.93 [0.79-1.10] 0.400 (2) 0.39 (236) 0.37 (179) 1.00 [0.77-1.31] 0.986 (2)
rs9331908 G 0.66 (1389) 0.69 (1161)   0.055 (1) 0.62 (1712) 0.66 (841)   0.036 (1) 0.66 (416) 0.69 (338)   0.297 (1)
Intron 4 A 0.34 (713) 0.31 (521) 1.18 [1.01-1.39] 0.035 (2) 0.38 (1046) 0.35 (443) 1.12 [0.96-1.30] 0.156 (2) 0.34 (214) 0.31 (152) 1.20 [0.91-1.56] 0.198 (2)
rs7982 C 0.63 (1228) 0.61 (1005)   0.191 (1) 0.67 (1780) 0.63 (804)   0.022 (1) 0.62 (374) 0.60 (295)   0.434 (1)
Exon 5 T 0.37 (734) 0.40 (657) 0.85 [0.73-0.99] 0.037 (2) 0.33 (884) 0.37 (470) 0.89 [0.76-1.03] 0.124 (2) 0.38 (234) 0.36 (167) 1.16 [0.89-1.52] 0.273 (2)
(B) Meta-analysis of stage I and II AD cohorts          
  Allele Summary OR p MH p Bonf p woolf'         
rs867230 T             
Intron 1 G 0.88 [0.79-0.97] 0.013 0.065 0.311         
rs1532278 G             
Intron 3 A 0.85 [0.77-0.94] 0.001 0.005 0.648         
rs11136000 G             
Intron 3 A 0.88 [0.79-0.97] 0.013 0.065 0.206         
rs9331908 G             
Intron 4 A 1.16 [1.04-1.28] 0.006 0.030 0.824         
rs7982 C             
Exon 5 T 0.89 [0.80-0.98] 0.023 0.115 0.448         
  1. (A) Allele frequencies are shown with absolute numbers in brackets. (1) The first p-value is the 2-sided p-value of the unadjusted χ2 statistics, (2) The second p-value is adjusted for age, APOE status and gender. Calculations of odds ratios (OR), presented with 95% confidence intervals (CI), were performed using the common allele as reference allele. (B) For meta-analysis, Mantel-Haenszel summary OR ratios are given with 95% CI and corresponding p-values (pMH) based on fixed-effects meta-analysis of age, gender and APOE- adjusted effect estimates of the minor allele. Nominal p-values (pmh, adjusted for age, gender and APOE effects) and Bonferroni corrected p-values (p Bonf) for the number of SNPs (N = 5) in the meta-analysis are given. P-values of Woolf's test for heterogeneity (p-woolf) are given.
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Molecular Neurodegeneration

ISSN: 1750-1326

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