Table 6 Common CLU associations with AD.

rs867230

T

0.63 (1259)

0.59 (952)

0.074 ⁽¹⁾

0.66 (1736)

0.62 (742)

0.022 ⁽¹⁾

0.60 (367)

0.63 (307)

0.288 ⁽¹⁾

Intron 1

G

0.37 (752)

0.41 (670)

0.82 [0.70-0.96]

0.012 ⁽²⁾

0.34 (904)

0.38 (456)

0.89 [0.76-1.04]

0.144 ⁽²⁾

0.40 (247)

0.37 (181)

1.04 [0.80-1.36]

0.771 ⁽²⁾

rs1532278

G

0.63 (1308)

0.61 (1006)

< 0.01 ⁽¹⁾

0.675 (1789)

0.628 (764)

0.004 ⁽¹⁾

0.62 (383)

0.62 (301)

0.996 ⁽¹⁾

Intron 3

A

0.37 (770)

0.40 (656)

0.83 [0.71-0.97]

0.019 ⁽²⁾

0.325 (861)

0.372 (452)

0.83 [0.71-0.97]

0.02 ⁽²⁾

0.38 (233)

0.38 (183)

1.27 [0.97-1.64]

0.078 ⁽²⁾

rs11136000

G

0.65 (1232)

0.61 (990)

0.034 ⁽¹⁾

0.66 (1707)

0.628 (764)

0.195 ⁽¹⁾

0.61 (372)

0.63 (299)

0.645 ⁽¹⁾

Intron 3

A

0.35 (676)

0.39 (630)

0.79 [0.68-0.93]

0.004 ⁽²⁾

0.34 (875)

0.372 (452)

0.93 [0.79-1.10]

0.400 ⁽²⁾

0.39 (236)

0.37 (179)

1.00 [0.77-1.31]

0.986 ⁽²⁾

rs9331908

G

0.66 (1389)

0.69 (1161)

0.055 ⁽¹⁾

0.62 (1712)

0.66 (841)

0.036 ⁽¹⁾

0.66 (416)

0.69 (338)

0.297 ⁽¹⁾

Intron 4

A

0.34 (713)

0.31 (521)

1.18 [1.01-1.39]

0.035 ⁽²⁾

0.38 (1046)

0.35 (443)

1.12 [0.96-1.30]

0.156 ⁽²⁾

0.34 (214)

0.31 (152)

1.20 [0.91-1.56]

0.198 ⁽²⁾

rs7982

C

0.63 (1228)

0.61 (1005)

0.191 ⁽¹⁾

0.67 (1780)

0.63 (804)

0.022 ⁽¹⁾

0.62 (374)

0.60 (295)

0.434 ⁽¹⁾

Exon 5

T

0.37 (734)

0.40 (657)

0.85 [0.73-0.99]

0.037 ⁽²⁾

0.33 (884)

0.37 (470)

0.89 [0.76-1.03]

0.124 ⁽²⁾

0.38 (234)

0.36 (167)

1.16 [0.89-1.52]

0.273 ⁽²⁾

(B) Meta-analysis of stage I and II AD cohorts

Allele

Summary OR

p _MH

p _Bonf

p _woolf'

rs867230

T

Intron 1

G

0.88 [0.79-0.97]

0.013

0.065

0.311

rs1532278

G

Intron 3

A

0.85 [0.77-0.94]

0.001

0.005

0.648

rs11136000

G

Intron 3

A

0.88 [0.79-0.97]

0.013

0.065

0.206

rs9331908

G

Intron 4

A

1.16 [1.04-1.28]

0.006

0.030

0.824

rs7982

C

Exon 5

T

0.89 [0.80-0.98]

0.023

0.115

0.448