(A) Allelic associations in stage I and II AD cohorts
         

 
BelgianFlanders
  
Lille
   
Toronto
   


Allele

AD (total)

C (total)

OR [95% CI]

p

AD (total)

C (total)

OR [95% CI]

p

AD (total)

C (total)

OR [95% CI]

p


rs867230

T

0.63 (1259)

0.59 (952)
 
0.074 ^{(1)}

0.66 (1736)

0.62 (742)
 
0.022
^{(1)}

0.60 (367)

0.63 (307)
 
0.288 ^{(1)}

Intron 1

G

0.37 (752)

0.41 (670)

0.82 [0.700.96]

0.012
^{(2)}

0.34 (904)

0.38 (456)

0.89 [0.761.04]

0.144 ^{(2)}

0.40 (247)

0.37 (181)

1.04 [0.801.36]

0.771 ^{(2)}

rs1532278

G

0.63 (1308)

0.61 (1006)
 
< 0.01
^{(1)}

0.675 (1789)

0.628 (764)
 
0.004
^{(1)}

0.62 (383)

0.62 (301)
 
0.996 ^{(1)}

Intron 3

A

0.37 (770)

0.40 (656)

0.83 [0.710.97]

0.019
^{(2)}

0.325 (861)

0.372 (452)

0.83 [0.710.97]

0.02
^{(2)}

0.38 (233)

0.38 (183)

1.27 [0.971.64]

0.078 ^{(2)}

rs11136000

G

0.65 (1232)

0.61 (990)
 
0.034
^{(1)}

0.66 (1707)

0.628 (764)
 
0.195 ^{(1)}

0.61 (372)

0.63 (299)
 
0.645 ^{(1)}

Intron 3

A

0.35 (676)

0.39 (630)

0.79 [0.680.93]

0.004
^{(2)}

0.34 (875)

0.372 (452)

0.93 [0.791.10]

0.400 ^{(2)}

0.39 (236)

0.37 (179)

1.00 [0.771.31]

0.986 ^{(2)}

rs9331908

G

0.66 (1389)

0.69 (1161)
 
0.055 ^{(1)}

0.62 (1712)

0.66 (841)
 
0.036
^{(1)}

0.66 (416)

0.69 (338)
 
0.297 ^{(1)}

Intron 4

A

0.34 (713)

0.31 (521)

1.18 [1.011.39]

0.035
^{(2)}

0.38 (1046)

0.35 (443)

1.12 [0.961.30]

0.156 ^{(2)}

0.34 (214)

0.31 (152)

1.20 [0.911.56]

0.198 ^{(2)}

rs7982

C

0.63 (1228)

0.61 (1005)
 
0.191 ^{(1)}

0.67 (1780)

0.63 (804)
 
0.022
^{(1)}

0.62 (374)

0.60 (295)
 
0.434 ^{(1)}

Exon 5

T

0.37 (734)

0.40 (657)

0.85 [0.730.99]

0.037
^{(2)}

0.33 (884)

0.37 (470)

0.89 [0.761.03]

0.124 ^{(2)}

0.38 (234)

0.36 (167)

1.16 [0.891.52]

0.273 ^{(2)}

(B) Metaanalysis of stage I and II AD cohorts
         

Allele

Summary OR

p
_{
MH
}

p
_{
Bonf
}

p
_{
woolf'
}
        
rs867230

T
            
Intron 1

G

0.88 [0.790.97]

0.013

0.065

0.311
        
rs1532278

G
            
Intron 3

A

0.85 [0.770.94]

0.001

0.005

0.648
        
rs11136000

G
            
Intron 3

A

0.88 [0.790.97]

0.013

0.065

0.206
        
rs9331908

G
            
Intron 4

A

1.16 [1.041.28]

0.006

0.030

0.824
        
rs7982

C
            
Exon 5

T

0.89 [0.800.98]

0.023

0.115

0.448
        
 (A) Allele frequencies are shown with absolute numbers in brackets. ^{(1)} The first pvalue is the 2sided pvalue of the unadjusted χ^{2} statistics, ^{(2)} The second pvalue is adjusted for age, APOE status and gender. Calculations of odds ratios (OR), presented with 95% confidence intervals (CI), were performed using the common allele as reference allele. (B) For metaanalysis, MantelHaenszel summary OR ratios are given with 95% CI and corresponding pvalues (p_{MH}) based on fixedeffects metaanalysis of age, gender and APOE adjusted effect estimates of the minor allele. Nominal pvalues (p_{mh}, adjusted for age, gender and APOE effects) and Bonferroni corrected pvalues (p _{Bonf}) for the number of SNPs (N = 5) in the metaanalysis are given. Pvalues of Woolf's test for heterogeneity (p_{woolf}) are given.