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Figure 8 | Molecular Neurodegeneration

Figure 8

From: Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer’s disease: a stochastic modelling approach

Figure 8

Simulated interventions. A Simulated vaccination with antibodies against Aβ dimers at different ages. B Simulated vaccination with antibodies against Aβ monomers at different ages. C Simulated inhibition of Aβ production by 25% at different ages. A-C Each point shows the percentage number of cells associated with plaques at age 100 years from 2000 simulations. The error bars show 95% confidence intervals for the percentages. Parameters used in A: k binantiAbDim  = 1.0e-7s-1, k prodantiAb  = 1.0 e-7s-1; parameters used in B: k binantiAbMon  = 1.0e-7s-1, k prodantiAb  = 1.0 e-5s-1.

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Molecular Neurodegeneration

ISSN: 1750-1326