TY - JOUR AU - Gass, Jennifer AU - Lee, Wing C. AU - Cook, Casey AU - Finch, Nicole AU - Stetler, Caroline AU - Jansen-West, Karen AU - Lewis, Jada AU - Link, Christopher D. AU - Rademakers, Rosa AU - Nykjær, Anders AU - Petrucelli, Leonard PY - 2012 DA - 2012/07/10 TI - Progranulin regulates neuronal outgrowth independent of Sortilin JO - Molecular Neurodegeneration SP - 33 VL - 7 IS - 1 AB - Progranulin (PGRN), a widely secreted growth factor, is involved in multiple biological functions, and mutations located within the PGRN gene (GRN) are a major cause of frontotemporal lobar degeneration with TDP-43-positive inclusions (FLTD-TDP). In light of recent reports suggesting PGRN functions as a protective neurotrophic factor and that sortilin (SORT1) is a neuronal receptor for PGRN, we used a Sort1-deficient (Sort1−/−) murine primary hippocampal neuron model to investigate whether PGRN’s neurotrophic effects are dependent on SORT1. We sought to elucidate this relationship to determine what role SORT1, as a regulator of PGRN levels, plays in modulating PGRN’s neurotrophic effects. SN - 1750-1326 UR - https://doi.org/10.1186/1750-1326-7-33 DO - 10.1186/1750-1326-7-33 ID - Gass2012 ER -