Figure 3
From: Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition
No significant change in cored plaques seen in AAV1-mIL-4 expressing TgCRND8 mice. A-B. Representative fluorescent images of Thioflavin S stained hippocampi from 5.5 month old TgCRND8 mice injected with rAAV2/1 mIL-4 (B) or rAAV2/1-EGFP (Control). Scale Bar, 200 μm. C. A comparison of the total number of Thioflavin S stained “cored” plaques from the forebrain of 5.5 month old TgCRND8 mice injected with rAAV2/1 mIL-4 or rAAV2/1-EGFP is depicted. Data represents mean ± sem. (n = 5/group; p = 0.0542, t test).