Skip to main content
Figure 1 | Molecular Neurodegeneration

Figure 1

From: Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

Figure 1

Immune response to 3A oligomer mimics. Serum from A11 vaccinated rabbits and 3A was used to probe dot blots containing Aβ monomer (1), Aβ prefibrillar oligomers (2), Aβ fibrils (3), calcitonin prefibrillar oligomers (4), IgG light chain prefibrillar oligomers (5) and synthetic KK(Q40)KK prefibrillar oligomers (6). It was observed that serum from 3A vaccinated rabbits reacted with all prefibrillar oligomer samples like A11 serum, but not Aβ monomer or Aβ fibrils. There was no immunoreactivity when using pre-immune serum.

Back to article page