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Figure 6 | Molecular Neurodegeneration

Figure 6

From: Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

Figure 6

Vaccination of animals at 3–14 months with antigens decreases anti CD45 reactivity. A. Following vaccination with 3A oligomer mimics significantly reduces the activated microglia. Representative photomicrographs of CD45 (brown) staining of brain sections from 14 months Tg2576 control, or vaccinated with Aβ oligomer, Aβ fibril, IAPP oligomer and 3A peptide. Scale bar 50 microns. B. Quantitation of CD45 immunoreactivity in cortex and hippocampus of animals immunized at 3–14 months. Mean of each animal is the average of two sections in which most to all the area of study was analyzed (4–8 images per section) Bars represent mean ± SD of n mice per group. *p < 0.02; CD45: Control n = 4, Aβ oligomer vaccinated n = 4, Aβ fibril vaccinated n = 4, IAPP oligomer vaccinated n = 4, 3A oligomer mimics vaccinated n = 4 *** p < 0.001.

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