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Figure 8 | Molecular Neurodegeneration

Figure 8

From: Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

Figure 8

No increase in incidence of microhemorrhage in 3A and IAPP oligomer mimic vaccinated mice. A. Representative images of Prussian blue stained sections. Arrowheads point to typical stage 1 microhemorrhages. Scale bar: 25 microns. B. The incidence of microhemorage was counted after staining for hemosiderin. Both the Aß oligomer mimic and Aß fibril vaccinated groups display a much higher incidence of microhemorrhage than the control, 3A or IAPP oligomer vaccinated groups. The mean counts from 3 different sections of each animal is shown +/− the standard error of the mean (n = 8). ***P < 0.001. The 3A oligomer mimics and IAPP vaccinated group.

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Molecular Neurodegeneration

ISSN: 1750-1326