Effects of LY window therapy on amyloid deposition. A. Time course of Aβ accumulation in Tg2576 mice. FA solubilized brain Aβ42 + Aβ40 levels measured by ELISA are shown (n = 3–5 mice/age group). B. Schematic of the various transient LY dosing strategies. Dotted lines represent the transient LY treatment time points. C. Aβ plaque burden analysis of treated cohorts compared to controls (*p < 0.05, ** ns, ANOVA). D. Biochemical analyses (FA solubilized Aβ42 + Aβ40 levels) by ELISA showing Aβ levels. (*p < 0.05, **ns, ANOVA). E. Representative brain sections stained with anti-Aβ mAb showing Aβ plaques at 15M of age in the LY treated cohorts. Scale bar = 100 μm.