Figure 2

Effects of LY window therapy on amyloid deposition. A. Quantitative burden analysis of cored amyloid deposits and CAA in the 4-7M LY treated group compared to controls. (*p < 0.05, Student’s t test). B. Representative brain sections stained with mAb 13.1.1 showing cored plaque and CAA immune-reactivity at 15M in the brains of Control and 4-7M LY treated Tg2576 mice. Arrows indicate CAA in meningeal vessels. Scale bar = 80 μm. C. Biochemical analyses of FA solubilized Aβ levels and plaque burden analysis from Tg2576 mice transiently dosed with LY (2.5mpk/day) from 4-7M, and aged to 18M. (*p < 0.05, Student’s t test). Tg2576 mice (n = 5-6/group) were used, data represented is from one independent experiment. D. Natural logarithm transformed Aβ values of untreated Tg2576 mice (at indicated ages) and Aβ levels from 4-7M LY treatment measured at 15M and 18M of age. E. Biochemical analyses of FA solubilized Aβ levels of Tg2576 mice transiently dosed with LY (2.5mpk/day) at 1, 2, and 3M intervals and then aged till 15M. (*p < 0.05, ANOVA). Tg2576 mice (n = 5-8/group) were used, data represented is from one independent experiment. F. Graph representing Aβ values of untreated Tg2576 mice (from indicated ages) and Aβ levels from 4-5M, 4-6M and 4-7M LY transient treatment measured at 15M. FA solubilized brain Aβ42 + Aβ40 levels measured by ELISA are shown.