Effect of LY treatment on peripheral immune cells. A. Distribution of splenic B cell (IgD, CD19) and T cells (CD4 and CD8) from control and Tg2576 mice treated with LY (4-7M). Percent positive cells are shown (n = 4 mice/group). B and C. IFN production (B) and IL-4 production (C) by CD4+ T cells from LY (4-7M) treated Tg2576 mice and untreated control mice were measured by ELISA. Equal numbers of purified, splenic CD4+ T cells (pooled from n =4 mice/group) were used. ND = not determined.