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Table 3 Quantification of clusterin in the human brain tissues

From: Mass spectrometry quantification of clusterin in the human brain

  Clusterin, pmol/mg tissue protein
  Frontal cortex Temporal cortex
  Control Severe AD Control Severe AD
ASSIIDELFQDR (Q1) 26.0 ± 4.2 39.6 ± 9.0 29.5 ± 7.4 24.2 ± 8.5
VTTVASHTSDSDVPSGVTEVVVK (Q5) 24.8 ± 4.7 38.6 ± 9.3 27.8 ± 7.9 29.3 ± 7.7
consensus 25.4 ± 4.4 39.1 ± 9.1 29.0 ± 7.9 28.0 ± 8.4
  1. Each control and severe AD group includes six human donors. The concentration was calculated for three experimental replicates by monitoring three transitions per individual peptide and presented as mean ± SD. The monitored transitions are summarized in Table 1. The reported phosphorylated Thr and Ser residues [10] are underlined. For the consensus, the data for both peptides were combined and presented as mean ± SD. Clusterin concentrations in frontal cortex were significantly different (P < 0.01) using a t test comparison for the control and severe AD groups, whereas clusterin concentrations in temporal cortex were not significantly different.