Table 1 Kinetic parameters of Aß40 and Aß42 degradation by BACE2
From: Identification of BACE2 as an avid ß-amyloid-degrading protease
Aß40 | Aß42 | |
|---|---|---|
K M (μM) | 2.8 ± 0.7 | 2.3 ± 0.6 |
V max (μM min -1 ) | 0.68 ± .083 | 0.12 ± 0.025 |
k cat (min -1 ) | 0.135 ± 0.016 | 0.025 ± 0.005 |
k cat / K M (M-1 min-1) | 4.82 x 107 | 1.07 x 107 |