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Table 1 Kinetic parameters of Aß40 and Aß42 degradation by BACE2

From: Identification of BACE2 as an avid ß-amyloid-degrading protease

  Aß40 Aß42
K M (μM) 2.8 ± 0.7 2.3 ± 0.6
V max (μM min -1 ) 0.68 ± .083 0.12 ± 0.025
k cat (min -1 ) 0.135 ± 0.016 0.025 ± 0.005
k cat / K M (M-1 min-1) 4.82 x 107 1.07 x 107
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Molecular Neurodegeneration

ISSN: 1750-1326