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Figure 5 | Molecular Neurodegeneration

Figure 5

From: IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery

Figure 5

IκBα cKO mice display increased BBB permeability and tissue damage after TBI. (A) Representative T1-weighted MRI images of Ctrl and cKO mice 3 hour and 3 day after TBI. Water droplets (separate circles in upper left) serve as the background control and uninjured areas (marked in yellow) are used as the internal control. Injured areas were marked in red. (B) Representative T2-weighted MRI images of Ctrl and cKO mice 3 hour and 3 day after TBI with the injured brain tissue marked in red. (C) Representative images of Nissl stained brain sections from mice survived 14 days after TBI. Scale bar: 1 mm. (D) Quantification of relative BBB permeability (normalized intensity) based on T1-weighted MRI images shown in (A). N = 3 for each group. (E) Quantification of total injury volume based on T2-weighted MRI images shown in (B). N = 3 for each group/time point. (F) Relative ventricular sizes were calculated as pixel numbers taken by ventricles divided by that of whole brain substances based on Nissl staining results. L-LV: left lateral ventricle, D-3 V: dorsal third ventricle, V-3 V: ventral third ventricle. N = 5-6 mice/genotype. *p < 0.05; **p < 0.01.

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Molecular Neurodegeneration

ISSN: 1750-1326