Exposure to Maneb and Paraquat alters adult neurogenesis in the hippocampus of α-Synuclein transgenic mice . Immunohistochemical detection of Doublecortin (DCX) positive neuronal precursors (A) and Proliferating cell nuclear antigen (PCNA) positive proliferating cells (C) in hippocampus of non-transgenic or Line 61 mice overexpressing human α-synuclein (E). Image analysis showing total counts of DCX (B) and PCNA (D) immunoreactive cells. (F) Optical density analysis showing accumulation of α-synuclein transgenic mice. Bar represents 10 μm. One way ANOVA or Student’s t test was used to determine statistical significance, *, # p<0.05.