Exposure to Maneb and Paraquat alters adult neurogenesis in the hippocampus of LRRK2(G2019S) transgenic mice . Immunohistochemical detection of Doublecortin (DCX) positive neuronal precursors (A) and Proliferating cell nuclear antigen (PCNA) positive proliferating cells (C) in hippocampus of non-transgenic or LRRK2(G2019S) mice. Image analysis showing total counts of DCX (B) and PCNA (D) immunoreactive cells. (E-F) Immunodetection and optical density analysis showing accumulation of phosphorylated Tau characteristic of LRRK2(G2019S) transgenic mice. Bar represents 10 μm. One way ANOVA or Student’s t test was used to determine statistical significance, *, # p<0.05.