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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease

Figure 2

Exposure to Maneb and Paraquat alters adult neurogenesis in the hippocampus of LRRK2(G2019S) transgenic mice . Immunohistochemical detection of Doublecortin (DCX) positive neuronal precursors (A) and Proliferating cell nuclear antigen (PCNA) positive proliferating cells (C) in hippocampus of non-transgenic or LRRK2(G2019S) mice. Image analysis showing total counts of DCX (B) and PCNA (D) immunoreactive cells. (E-F) Immunodetection and optical density analysis showing accumulation of phosphorylated Tau characteristic of LRRK2(G2019S) transgenic mice. Bar represents 10 μm. One way ANOVA or Student’s t test was used to determine statistical significance, *, # p<0.05.

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Molecular Neurodegeneration

ISSN: 1750-1326