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Table 1 Genetic Effects: genes dysregulated in PD transgenic mice models

From: Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease

Accession Fold change Gene title Gene symbol Functional Group
(A) mThy-α-synuclein transgenic (Line 61)
NM_145990 −1.56 CDK5 regulatory subunit associated protein 2 Cdk5rap2 Cell differentiation
NM_008711 −1.44 Noggin Nog
NM_008380 −1.34 Inhibin beta-A Inhba
NM_010894 −1.26 Neurogenic differentiation 1 Neurod1
NM_009170 −1.21 Sonic hedgehog Shh
NM_008744 −1.33 Netrin 1 Ntn1 Cell motility and migration
NM_021409 −1.30 Par-6 (partitioning defective 6) homolog beta (C. elegans) Pard6b
NM_010275 −1.46 Glial cell line derived neurotrophic factor Gdnf Growth factors
NM_013904 −1.26 Hairy/enhancer-of-split related with YRPW motif 2 Hey2 Transcription
NM_007889 −1.24 Dishevelled 3, dsh homolog (Drosophila) Dvl3 Cell signaling
(B) mThy-LRRK2 mut G2019S (Line G2019S)
NM_145990 1.58 CDK5 regulatory subunit associated protein 2 Cdk5rap2 Cell differentiation
NM_009630 −1.27 Adenosine A2a receptor Adora2a Cell signaling, apoptosis
NM_022312 −1.24 Tenascin R Tnr Cell adhesion
  1. Comparison of gene expression between each of the transgenic lines studied with their corresponding non-transgenic littermates treated with saline. P<0.05 per Student’s t test.