Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease

Table 1 Genetic Effects: genes dysregulated in PD transgenic mice models

Accession	Fold change	Gene title	Gene symbol	Functional Group
*(A) mThy-α-synuclein transgenic (Line* *61)*
NM_145990	−1.56	CDK5 regulatory subunit associated protein 2	Cdk5rap2	Cell differentiation
NM_008711	−1.44	Noggin	Nog
NM_008380	−1.34	Inhibin beta-A	Inhba
NM_010894	−1.26	Neurogenic differentiation 1	Neurod1
NM_009170	−1.21	Sonic hedgehog	Shh
NM_008744	−1.33	Netrin 1	Ntn1	Cell motility and migration
NM_021409	−1.30	Par-6 (partitioning defective 6) homolog beta (C. elegans)	Pard6b	Cell motility and migration
NM_010275	−1.46	Glial cell line derived neurotrophic factor	Gdnf	Growth factors
NM_013904	−1.26	Hairy/enhancer-of-split related with YRPW motif 2	Hey2	Transcription
NM_007889	−1.24	Dishevelled 3, dsh homolog (Drosophila)	Dvl3	Cell signaling
*(B) mThy-LRRK2 mut G2019S* *(Line G2019S)*
NM_145990	1.58	CDK5 regulatory subunit associated protein 2	Cdk5rap2	Cell differentiation
NM_009630	−1.27	Adenosine A2a receptor	Adora2a	Cell signaling, apoptosis
NM_022312	−1.24	Tenascin R	Tnr	Cell adhesion

Comparison of gene expression between each of the transgenic lines studied with their corresponding non-transgenic littermates treated with saline. P<0.05 per Student’s t test.

ISSN: 1750-1326