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Table 2 Environmental effects: genes dysregulated in response to MB/PQ

From: Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease

Accession

Fold change

Gene title

Gene symbol

Functional Group

NM_007488

1.25

Aryl hydrocarbon receptor nuclear translocator 2

Arnt2

Transcription

NM_194053

1.22

Reticulon 4

Rtn4

Apoptosis

NM_145990

1.24

CDK5 regulatory subunit associated protein 2

Cdk5rap2

Cell differentiation

NM_008380

−1.54

Inhibin beta-A

Inhba

NM_008711

−1.27

Noggin

Nog

NM_010894

−1.23

Neurogenic differentiation 1

Neurod1

NM_008744

−1.40

Netrin 1

Ntn1

Cell motility

NM_007540

−1.35

Brain derived neurotrophic factor

Bdnf

Growth factors

NM_022312

−1.23

Tenascin R

Tnr

Cell adhesion

NM_174991

−1.21

Brain-specific angiogenesis inhibitor 1

Bai1

Cell proliferation

  1. Comparison of gene expression between non-transgenic animals treated with Maneb/Paraquat with non-transgenic animals treated with saline as control group. P<0.05 per Student’s t test.
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Molecular Neurodegeneration

ISSN: 1750-1326