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Table 3 Gene x Environment Interaction: genes altered by MB/PQ in α-syn-Tg

From: Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease

Accession Fold change Gene title Gene symbol Functional Group
NM_145990 −2.35 CDK5 regulatory subunit associated protein 2 Cdk5rap2 Cell differentiation
NM_007865 −1.82 Delta-like 1 (Drosophila) Dll1
NM_008380 −1.80 Inhibin beta-A Inhba
NM_008711 −1.68 Noggin Nog
NM_010894 −1.33 Neurogenic differentiation 1 Neurod1
NM_009170 −1.33 Sonic hedgehog Shh
NM_008553 −1.26 Achaete-scute complex homolog 1 (Drosophila) Ascl1
NM_008782 −1.24 Paired box gene 5 Pax5
NM_010275 −1.25 Glial cell line derived neurotrophic factor Gdnf Growth factors
NM_009505 −1.33 Vascular endothelial growth factor A Vegfa
NM_007553 −1.28 Bone morphogenetic protein 2 Bmp2
NM_007554 −1.25 Bone morphogenetic protein 4 Bmp4
NM_010077 −1.31 Dopamine receptor D2 Drd2 Synaptic transmission
NM_013503 −1.23 Dopamine receptor D5 Drd5
NM_013904 −1.64 Hairy/enhancer-of-split related with YRPW motif 2 Hey2 Transcription
NM_013905 −1.61 Hairy/enhancer-of-split related with YRPW motif-like Heyl
NM_007889 −1.52 Dishevelled 3, dsh homolog (Drosophila) Dvl3 Cell signaling
NM_001008533 −1.30 Adenosine A1 receptor Adora1
NM_008744 −1.39 Netrin 1 Ntn1 Cell motility
NM_174991 −1.28 Brain-specific angiogenesis inhibitor 1 Bai1 Cell proliferation
NM_022312 −1.27 Tenascin R Tnr Cell adhesion
NM_013660 −1.26 Sema domain, Ig domain, transmembrane domain and short cytoplasmic domain, 4D Semad4 Apoptosis
NM_009685 −1.38 Amyloid beta (A4) precursor protein-binding, family B,1 Apbb1 Cell cycle
  1. Comparison of gene expression between mThy-α-synuclein transgenic mice treated with Maneb/Paraquat, with their corresponding non-transgenic littermates treated with saline. P<0.05 per Student’s t test. Bold italic fonts denote genes also affected by genetic background or pesticides independently.