Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease

Table 4 Gene x Environment Interaction: genes altered by MB/PQ in LRRK2-Tg

Accession	Fold Change	Gene title	Gene symbol	Functional Group
NM_145990	1.32	CDK5 regulatory subunit associated protein 2	*Cdk5rap2*	Cell differentiation
NM_178591	−1.37	Neuregulin 1	Nrg1
NM_025876	−1.32	CDK5 regulatory subunit associated protein 1	Cdk5rap1
NM_008380	−1.31	Inhibin beta-A	*Inhba*
NM_013627	−1.29	Paired box gene 6	Pax6
NM_010894	−1.26	Neurogenic differentiation 1	*Neurod1*
NM_009170	−1.24	Sonic hedgehog	*Shh*
NM_009871	−1.22	CDK5 regulatory subunit 1 (p35)	Cdk5r1
NM_007540	−1.24	Brain derived neurotrophic factor	*Bdnf*	Growth factors
NM_009505	−1.23	Vascular endothelial growth factor A	*Vegfa*
NM_007554	−1.23	Bone morphogenetic protein 4	*Bmp4*
NM_013904	−1.30	Hairy/enhancer-of-split related with YRPW motif 2	*Hey2*	Transcription
NM_008900	−1.26	POU domain, class 3, transcription factor 3	Pou3f3
NM_007488	−1.24	Aryl hydrocarbon receptor nuclear translocator 2	*Artn2*
NM_022312	−1.27	Tenascin R	*Tnr*	Cell adhesion
NM_010110	−1.21	Ephrin B1	Efnb1
NM_183171	−1.21	Fasciculation and elongation protein zeta 1 (zygin I)	Fez1
NM_174991	−1.37	Brain-specific angiogenesis inhibitor 1	*Bai1*	Cell proliferation
NM_010883	−1.21	Norrie disease (pseudoglioma)	Ndph	Cell proliferation
NM_203491	−1.24	Cholinergic receptor, muscarinic 2	Chrm2	Synaptic functions
NM_009599	−1.21	Acetylcholinesterase	Ache	Synaptic functions
NM_008744	−1.39	Netrin 1	*Ntn1*	Cell motility and migration

Comparison of gene expression between mThy-LRRK2(G2019) transgenic mice treated with Maneb/Paraquat, with their corresponding non-transgenic littermates with saline. P<0.05 per Student’s t test. Bold italic fonts denote genes also affected by genetic background or pesticides independently.

ISSN: 1750-1326