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Table 4 Gene x Environment Interaction: genes altered by MB/PQ in LRRK2-Tg

From: Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease

Accession Fold Change Gene title Gene symbol Functional Group
NM_145990 1.32 CDK5 regulatory subunit associated protein 2 Cdk5rap2 Cell differentiation
NM_178591 −1.37 Neuregulin 1 Nrg1
NM_025876 −1.32 CDK5 regulatory subunit associated protein 1 Cdk5rap1
NM_008380 −1.31 Inhibin beta-A Inhba
NM_013627 −1.29 Paired box gene 6 Pax6
NM_010894 −1.26 Neurogenic differentiation 1 Neurod1
NM_009170 −1.24 Sonic hedgehog Shh
NM_009871 −1.22 CDK5 regulatory subunit 1 (p35) Cdk5r1
NM_007540 −1.24 Brain derived neurotrophic factor Bdnf Growth factors
NM_009505 −1.23 Vascular endothelial growth factor A Vegfa
NM_007554 −1.23 Bone morphogenetic protein 4 Bmp4
NM_013904 −1.30 Hairy/enhancer-of-split related with YRPW motif 2 Hey2 Transcription
NM_008900 −1.26 POU domain, class 3, transcription factor 3 Pou3f3
NM_007488 −1.24 Aryl hydrocarbon receptor nuclear translocator 2 Artn2
NM_022312 −1.27 Tenascin R Tnr Cell adhesion
NM_010110 −1.21 Ephrin B1 Efnb1  
NM_183171 −1.21 Fasciculation and elongation protein zeta 1 (zygin I) Fez1  
NM_174991 −1.37 Brain-specific angiogenesis inhibitor 1 Bai1 Cell proliferation
NM_010883 −1.21 Norrie disease (pseudoglioma) Ndph
NM_203491 −1.24 Cholinergic receptor, muscarinic 2 Chrm2 Synaptic functions
NM_009599 −1.21 Acetylcholinesterase Ache
NM_008744 −1.39 Netrin 1 Ntn1 Cell motility and migration
  1. Comparison of gene expression between mThy-LRRK2(G2019) transgenic mice treated with Maneb/Paraquat, with their corresponding non-transgenic littermates with saline. P<0.05 per Student’s t test. Bold italic fonts denote genes also affected by genetic background or pesticides independently.