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Figure 2 | Molecular Neurodegeneration

Figure 2

From: WldS but not Nmnat1 protects dopaminergic neurites from MPP+neurotoxicity

Figure 2

Cytoplasmic Wlds protects dopaminergic neurons from MPP+ toxicity. (A) Dissociated dopaminergic cultures from both WT and cyto Wlds mice were co-stained with TH and Wlds antibodies to confirm the subcellular localization of Wlds. (B) Cultures were treated with 2 μm MPP+ for 48 hours prior to fixing and staining. (C) Quantification of TH+ cell bodies and (D) TH+ neurites shows that cytoplasmic WldS protected both cell bodies and neurites against MPP+. Data are normalized to control cultures and denote the mean ± SEM of representative determinations made in three separate cultures. *p < 0.05.

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