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Figure 4 | Molecular Neurodegeneration

Figure 4

From: WldS but not Nmnat1 protects dopaminergic neurites from MPP+neurotoxicity

Figure 4

Wlds and cytoplasmic Nmnat1 protect DRG axons from vincristine toxicity. (A) DRG cultures from E14 mice transduced with GFP, Wlds, cyto Nmnat1, or inactive Wlds were processed for acetylated tubulin immunoreactivity 24 hours after vincristine treatment. Inserts in bottom middle panels show 40× images of DRG cell bodies transduced with Wlds and cytoplasmic Nmnat1, respectively, to illustrate no overt nuclear enrichment of Nmnat1. (B) Quantification of neurites shows that both Wlds and cyto Nmnat1 protects DRG neurites from vincristine toxicity. Data are normalized to control cultures and denote the mean ± SEM of representative determinations made in three separate cultures. *p < 0.05.

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