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Table 1 Summary of subject information presented in Figure 6 B and C

From: Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease

Sample no.

Subject

Age

Sex

Post mortem time (min)

Braak stage

Seizure

Relative ratio (protein/tubulin)

Actin

APP

HCN1

1

Normal

84

F

877

1

-

0.929

1.192

0.809

2

Normal

88

F

144

1

-

0.856

1.046

0.859

3

Normal

70

M

340

0.5

-

0.955

1.189

0.859

4

AD

84

M

71

4

-

0.950

1.171

0.952

5

AD

70

M

276

4

-

0.829

0.986

0.716

6

AD

74

M

322

5

-

0.961

0.990

0.827

7

AD

75

M

594

6

-

1.069

1.176

0.589

8

AD

76

M

947

6

+

1.190

1.167

0.273

9

AD

79

F

203

5

-

1.019

0.913

0.317

10

AD

81

M

360

6

-

0.971

0.862

0.247

11

AD

81

F

442

5

-

0.971

0.862

0.385

12

AD

82

F

254

6

-

0.988

1.029

0.313

13

AD

82

F

533

5

-

0.988

1.001

0.566

14

AD

82

F

338

4

-

1.028

1.063

0.770

15

AD

84

M

590

5

-

1.071

1.128

0.876

16

Normal

78

F

87

2

-

1.108

1.138

2.153

17

Normal

81

M

134

1

-

1.122

0.971

0.902

18

Normal

82

F

148

1

-

1.178

1.109

1.963

19

Normal

82

F

155

2

-

1.141

1.026

0.821

20

Normal

80

M

317

2

-

1.254

1.037

0.893

21

Normal

80

M

510

2

-

1.071

0.778

0.669

22

Normal

82

M

530

1

-

0.979

0.916

0.384

23

Normal

78

M

575

1

-

0.905

1.007

0.713

24

Normal

78

M

690

1

-

0.784

0.986

1.479

25

Normal

82

M

736

1

-

0.774

0.743

1.448

  1. Postmortem brain samples were obtained from the Brain Bank for Aging Research, Tokyo Metropolitan Institute of Gerontology. Experimental procedures were approved by the appropriate ethical boards at each institute. Autopsies were performed with written informed consent from the patients or their relatives. The clinical diagnosis of AD was based on two major criteria: the Diagnostic and Statistical Manual of Mental Disorders: 4th Edition (DSM-IV) and the National Institute of Neurological and Communicational Disorders and Stroke-Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA). The neuropathological diagnosis of AD was made using Consortium to Establish a Registry for Alzheimer’s Disease criteria (average age at death, 79.2 ± 4.4 years). Control brains were obtained from age-matched individuals with no history of neurological or psychiatric illness (average age at death, 80.4 ± 4.2 years). Subjects, age, gender, postmortem time, Braak stage, seizure history, and relative protein/tubulin ratios are indicated.