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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP

Figure 2

The TDP-43 target gene G3BP is required for SG assembly. (A) Western blot to confirm efficacy of indicated siRNAs in HeLa (left panel) and in SK-N-SH (right panel) cells. Actin serves as a loading control. (B) Quantification of protein levels demonstrating that G3BP does not regulate TDP-43 in HeLa (left panel) nor in SK-N-SH (right panel). (C & D) Quantification of individual SG size and number in siRNA treated cells, at 60 and 90 min after SA treatment in (C) HeLa cells and (D) SK-N-SH cells. The means of 3 independent experiments ± SEM are plotted. * p < 0.05. siControl in Figure 2C is the same presented in Figure 4A,B. siControl in Figure 2D is the same presented in Figure 1C.

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