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Table 1 Summary of cell and neuron counts from different studies according to brain region and counting method

From: The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease

Method

Genetic background

Brain region

Cell or neuron number

Age of animals and transgene(s) harbored

Reference

Isotropic Fractionator

TgCRND8 (C3H/He-C57BL/6)

Whole brain

100.10 ± 7.90 x 106

6 months; K670M/N671L/V717F APP

Present study

 

Dutch (C57BL/6J)

    

Isotropic Fractionator

Swiss Webster

Whole brain

108.90 ± 16.25 x 106

2-5 months

7

Isotropic Fractionator

TgCRND8 (C3H/He-C57BL/6)

Cerebellum

43.92 ± 2.78 x 106

6 months; K670M/N671L/V717F APP

Present study

 

Dutch (C57BL/6J)

    

Isotropic Fractionator

Swiss Webster

Cerebellum

49.17 ± 5.32 x 106

2-5 months

7

Isotropic Fractionator/Flow Cytometry

C57Bl/6J

Cerebellum

44.03 ± 0.42 x 106

60-100 days

8

Isotropic Fractionator

TgCRND8 (C3H/He-C57BL/6)

Hippocampus

31.8% decrease in neurons

6 months; K670M/N671L/V717F APP

Present Study

Isotropic Fractionator

Dutch (C57BL/6J)

Hippocampus

No decrease in neurons

18 month Dutch E693Q APP mice

Present study

Stereology

C57BL/6

CA1

~25% decrease in neurons

14-18 month-old TgAPP23 (K670M/N671L) mice

9

Stereology

APP/ PS1M146L (CBA - 12.5% × C57Bl6 - 87.5%)

CA1-CA3

~30% decrease in neurons

17 month APP (751SL) and presenilin 1 (PS1M146L) mice

10

 

Controls (C57BL/6)

    

Stereology

(C57BL/6 50%-CBA 25%–129SV 25%)

CA1/2

~50% decrease in neurons

10 month APPSLPS1KI (APP K670N/M671L, and V717I; PS1 M233T/L235P knock-in)

11

Stereology

C57BL/6J

CA1

33% decrease in neurons

6 month APP/PS1KI

12

    

(APP K670N/M671L, and V717I; PS1 M233T/L235P knock-in)