Figure 3

Schematic diagram showing the cascade of molecular changes initiated by an injury to the spinal cord, which leads to neuronal dysfunction and death. Those genes thought to be able to modify the effect of trauma (Table 1) have the potential to alter each of the reported molecular pathways, by inhibition (red line) or by activation of a specific response (green arrow), thus changing the overall molecular profile in the injured tissue and affecting the rate of neuronal death.