Skip to main content

Table 1 Gene modifiers of the response to spinal cord injury and/or to neurotrauma.

From: Spinal cord trauma and the molecular point of no return

Gene variant Experimental paradigm Gene function Neuropathology References
ApoE Human and ApoE -/- animal models Lipid transport Neurofibrillary tangles Jordan et al., 1997
Saunders et al., 1993
Setzer et al., 2008
ABCD1 Human carriers Transport and metabolise very long-chain fatty acids Axonal demylination Berger & Gartner, 2006
Fatemi et al., 2003
Raymond et al., 2010
Bach1 Bach -/- mice Pro-oxidant; (transcriptional repressor of heme oxygenase-1) Cellular death Kanno et al., 2009
Yamada et al., 2008
SOD1 Animal models Oxidative stress, apoptosis, inflammation, neurofilaments, lipid metabolism Neuronal death, Reactive astrogliosis Jokic et al., 2010
Sharp et al., 2005
TDP-43 Human trauma and Nerve injury animal models DNA, RNA and protein binding Neuronal death Mckee et al., 2010
Moisse et al., 2009
SEPT9 Humans Cytoskeleton, cell division, tumorigenesis Axonal degeneration Kuhlenbaumer et al., 2005
MHC2TA Root avulsion animal models Major MHC class II Neuronal death Harnesk et al., 2008
Piehl et al., 2007
Beta App Human trauma and injury animal models Protein cleavage, oxidative stress Neurofibrillary tangles Li et al., 1995
Uryu et al., 2002
Uryu et al., 2007
FGF Dominant negative animals Angiogenesis, wound healing, embryonic development Cellular death Eckenstein et al., 2006
HSP Animal models Molecular chaperones, oxidative stress, apoptosis Neuronal death Reddy et al., 2008
  1. The table details for each gene, the experimental context where the effect of the gene was tested and the molecular pathways through to be implicated in the specific gene-driven molecular response to trauma.