Figure 10

Chronic daily exposure to EVP-0015962 in Tg2576 mice reverses a cognitive decline. A. Percent freezing in the CFC behavioral assay after chronic treatment with EVP-0015962 for 11 weeks in wild type (WT) and Tg2576 (Tg) mice, aged 30–33 weeks. Difference between WT and Tg2576 mice on control diet (i.e., genotype effect): ⁺⁺p < 0.01. Differences from Tg2576 mice on control diet (i.e., treatment effect): **p < 0.01. N = 10–15 mice per group. B. Percent freezing comparing WT and Tg2576 at 30 weeks of age and treated with a single acute dose of 30 mg/kg, p.o. of EVP-0015962 or vehicle. Differences from WT mice receiving the same treatment, either vehicle or 30 mg/kg of EVP-0015962: ⁺p < 0.05, indicating a genotype effect but no treatment effect. N = 10–15 mice per group. All statistical analyses were performed with 1-way ANOVAs and post-hoc Newman-Keuls tests or t-tests.