Figure 5
In Tg2576 mice, a single dose of EVP-0015962 decreases brain Aβ 42 without altering Aβ Total . Brain concentrations of Aβ42 (A) and AβTotal (B), measured 4 h after 10 or 30 mg/kg, p.o. of EVP-0015962 by sandwich ELISAs, following TBS extraction. Graphs illustrate mean + SEM, N = 4 per group. Difference from the vehicle-treated group: *p < 0.05 (1-way ANOVA, post-hoc Newman-Keuls test).