Chronic daily exposure to EVP-0015962 in Tg2576 mice is well tolerated. Body weight change in Tg2576 mice, measured weekly beginning the week prior to chronic dosing with EVP-0015962 in a food formulation at 20 or 60 mg/kg/day and continuing through the course of treatment. There are no group differences in body weight change (2-way repeated measures ANOVA, within subjects variable – week and between subjects variable – drug treatment). Data are the mean ± SEM of 6–8 mice per group. Arrow indicates the start of treatment with EVP-0015962.