Chronic daily exposure to EVP-0015962 in Tg2576 mice reduces Aβ without affecting APP α- and β-CTFs. A. Aggregated Aβ, measured by the A4 assay and expressed as a percent of the control diet group in 17-month-old mice. N = 9–10 mice per group. Difference from the control diet group: **p < 0.01 (Kruskal-Wallis ANOVA, post-hoc Dunn’s test). B. Representative Western blot for the different peptide species of APP for Tg2576 mice on the control diet and treated with 20 or 60 mg/kg/day of EVP-0015962. C. Quantification of relative optical density (ROD) from Western blots for full length APP (flAPP), β-CTF, and α-CTF. D. Quantification of ROD from Western blots for Total Aβ. N = 3–4 mice per group. Graphs illustrate mean + SEM. Differences from the control diet group: **p < 0.01, ***p < 0.001 (1-way ANOVA, post-hoc Newman-Keuls test).