Figure 9

Chronic daily exposure to EVP-0015962 in Tg2576 mice reduces Aβ deposition and reactive gliosis. Representative sections illustrating staining of amyloid plaques with ThioflavinS (green) and by immunohistochemistry (6E10, red) in the subiculum of the hippocampus from Tg2576 mice fed either a control diet (A) or treated with 20 mg/kg/day of EVP-0015962 (B). Representative sections illustrating immunohistochemical staining of reactive astrocytes (GFAP, green) and activated microglia (CD11b, red) in the subiculum from Tg2576 mice, fed either a control diet (C) or treated with 60 mg/kg/day of EVP-0015962 (D). Nuclei are stained with 4',6-diamidino-2-phenylindole (DAPI, blue). In C, amyloid deposits are visualized by the presence of interspersed fine microglial processes and are surrounded by activated microglia and in turn by GFAP-positive astrocytes.