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Figure 10 | Molecular Neurodegeneration

Figure 10

From: Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice

Figure 10

VAPBP56S and SOD1G93A aggregates did not interact with each other. (A). Mouse spinal cord lysates were centrifuged to separate the soluble and insoluble fractions. One hundred μg of both fractions were loaded on the gel and blotted for VAPB, FLAG, SOD1 and tubulin. The asterisks mark the 3XFLAG tagged VAPB, which is above the endogenous mouse VAPB. (B). muVAPB and SOD1G93A aggregate independent of each other in the same motor neuron in the spinal cord of the muVAPB35 and SOD1G93A double transgenic mice. The sections from the lumbar spinal cord were stained with VAPB and hSOD1 antibodies. The nuclei were shown by DAPI stain. Scale bar: 5 μm.

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Molecular Neurodegeneration

ISSN: 1750-1326