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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice

Figure 3

Age-associated changes in body weight and motor function in VAPB transgenic mice. (A) No significant difference in the body weight between female muVAPB and NTG mice up to 600 days old. For each time point, 6 to 21 mice from each genotype were analyzed. (B) No significant difference among muVAPB35/60 (n = 4), muVAPB35 (n = 11) and NTG (n = 11) mice in rotarod test at the age of 10 to 12 months. (C, D) Grip strength tests of the forelimbs (C) and combined forelimbs and hindlimbs (D) in female NTG and muVAPB35 transgenic mice at different ages. The number of mice tested from each genotype at each time point is in the range of 4 to 22. All values are displayed as averages with standard deviation.

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Molecular Neurodegeneration

ISSN: 1750-1326