Skip to main content
Figure 5 | Molecular Neurodegeneration

Figure 5

From: Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice

Figure 5

No significant TDP-43 pathology and ubiquitin-positivity in the muVAPB transgenic mice. (A) No TDP-43 aggregation or change in its cellular distribution in the spinal cords of VAPB transgenic mice was detected. Frozen sections from lumbar spinal cords from NTG, wtVAPB and muVAPB35/60 mice at 18-month old were stained with VAPB and TDP-43 antibodies. Scale bars: 10 μm. (B) Ubiquitin staining was absent or weak in motor neurons with muVAPB aggregates. Frozen sections from cervical spinal cords from NTG and muVAPB35/60 at 18-month old were stained with ubiquitin and VAPB antibodies. The sections from mutant SOD1 mice at their end stage were stained in parallel as positive controls. Scale bars: 6 μm. The VAPB aggregates are indicated by arrows in the figure. The nuclei are shown by DAPI stain.

Back to article page