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Figure 9 | Molecular Neurodegeneration

Figure 9

From: Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice

Figure 9

Overexpression of neither wtVAPB nor muVAPB significantly impacted on the disease progression and survival of SOD1G93A mice. (A) The effect of overexpression of muVAPB on the weight changes in SOD1G93A mice. The weight data of the male mice from SOD1G93A (n = 12), SOD1G93A and muVAPB35 double transgenic (n = 10), SOD1G93A and muVAPB35/60 triple transgenic mice (n = 10) were analyzed. (B) The survival of the male mice from SOD1G93A (n = 27), SOD1G93A and muVAPB35 double transgenic (n = 27), SOD1G93A and muVAPB35/60 triple transgenic (n = 27), and SOD1G93A and wtVAPB double transgenic mice (n = 6) were analyzed.

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Molecular Neurodegeneration

ISSN: 1750-1326