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Figure 2 | Molecular Neurodegeneration

Figure 2

From: In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

Figure 2

Bexarotene increases ISF apoE levels and decreases ISF Aβ levels. A. ISF Aβx-40 and apoE levels in the hippocampus of 2-month old APP/PS1 mice were monitored using in vivo microdialysis. Following establishment of a 6 hour baseline ISF level for Aβx-40 and apoE, mice were administered bexarotene (100 mg/kg p.o.) or vehicle (water) and ISF Aβx-40 and apoE levels assessed for an additional 36 hours. B. The mean percent change from baseline of ISF apoE and Aβx-40 levels 30-36 post-administration was compared between vehicle and bexarotene treated mice. Bexarotene significantly increased ISF apoE levels (247 ± 34.3%, n=2) compared to vehicle (103 ± 5.2%, n=3) (*p<0.05, unpaired t-test). Bexarotene decreased ISF Aβ levels (65.1 ± 8.1%, n=3) compared to vehicle (100 ± 3.7%, n=6). (**p<0.005, unpaired t-test).

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