Impact of 6-OHDA lesions on anxious and depressive-like behavior. A) Related to sham animals incomplete and complete lesion groups show no signs for increased anxiety, as seen by open arms/closed arms time ratio on the elevated-plus maze (EPM). B) Assessment of acoustic startle response shows no signs of anxious-like behavior in both lesioned groups V-Avg = average startle response (arbitrary units). dB = decibels. C) Compared to sham animals, 6-OHDA lesions caused anhedonic behavior in the sucrose preference test in both incomplete and complete lesion groups Data presented as mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001, related to incomplete lesion, † p < 0.05, related to complete lesion. For EPM and acoustic startle sham n = 17; incomplete lesion n = 12; complete lesion n = 24. For sucrose preference test sham n = 17; incomplete lesion n = 12; complete lesion n = 28.