Figure 5

Effect of dopaminergic and antidepressant therapy of animals with complete DA unilateral lesions. A) On the open field arena bupropion (BUP) treatment significantly rescued spontaneous locomotion, whereas levodopa (LD) had a partial effect. Paroxetine (PRX) had no effect, related to vehicle-treated animals. B) BUP treatment improved motor initiation in the open field, while the effect of LD was partial. PRX had no effect when compared to vehicle treatment. C) Anhedonic behavior was significantly improved with LD treatment and partially by BUP, compared to vehicle-treated animals, while PRX showed no effect. Data presented as mean ± SEM. * p < 0.05, ** p < 0.01. Results from an additional set of animals distributed as following according to treatment: Vehicle n = 37; LD n = 10; PRX = Paroxetine n = 10; BUP = Bupropion n = 9.