Figure 3

Exploratory activity and motor coordination in BRI2-Aβ mice. (A) The proportion of the exploration of center of the arena to total exploration path during the open-field test carried out at the age of 14.4 months. (B) Latency to fall from the accelerating rotarod performed at the age of 14.6 months. (C) Swim paths of 15.1 month-old mice to a visible platform in WM. (D) Path tortuosity, expressed as the sum of absolute changes in walking direction divided by total path length. The lower tortuosity of BRI2-Aβ42 mice during first session (S1) did not differentiate the genotypes (F(2,24) = 2.3, p = 0.1), and the tortuosity of these mice did not differ from tortuosity of both BRI2-Aβ40 and non-Tg mice (p = 0.4 and p = 0.15, respectively, t-test with Bonferroni adjustment). Error bars represent s.e.m.